Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 16/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | BLK | P51451 | 2/20 | 0.41 |
| ▸ | STK3 | Q13188 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836940 | 0.88 | KDR (0.60) | BRD4CREBBPKDRCYP17A1RIPK3 | |
| SCHEMBL3039531 | 0.72 | KDR (0.34) | KDRPIM1ROCK1CLK4 | |
| SCHEMBL3835838 | 0.72 | TDP2 (0.42) | BRD4CREBBPKDRMAP4K4 | |
| SCHEMBL3039949 | 0.71 | MAP3K9 (0.50) | KDRPIM1ROCK1PRKD3NTRK2 | |
| SCHEMBL3840842 | 0.70 | KDR (0.71) | KDRROCK2RETAURKBFLT1 | |
| SCHEMBL13754832 | 0.70 | CYP17A1 (0.64) | BRD4CREBBPCYP17A1 | |
| SCHEMBL18170628 | 0.70 | KDR (0.70) | KDRROCK2RETAURKBFLT1 | |
| SCHEMBL29029431 | 0.69 | HDAC3 (0.56) | BRD4CREBBPCYP17A1 | |
| SCHEMBL3785736 | 0.69 | BRD4 (0.53) | BRD4CREBBPCYP17A1MAP4K4 | |
| SCHEMBL5846227 | 0.69 | GPR119 (0.53) | BRD4CREBBPCYP17A1NTRK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |