SCHEMBL3839738

SCHEMBL3839738

Nc1ccc(-c2ccc(N(c3ccccc3)c3ccccc3)c(-c3ccc(Br)cc3)c2-c2ccc(Br)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
CYP3A4 P08684 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
MAPT P10636 2/20 0.43
CYP1A2 P05177 2/20 0.43
KDM4E B2RXH2 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MAPK1 P28482 2/20 0.37
ALOX15 P16050 1/20 0.37
TAAR1 Q96RJ0 1/20 0.35
HSD17B10 Q99714 1/20 0.35
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
ACHE P22303 1/20 0.31
CYP1A1 P04798 1/20 0.30
CYP1B1 Q16678 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL297638 0.91 ALDH1A1 (0.48) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL29475171 0.90 ALDH1A1 (0.56) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL10522612 0.88 ALDH1A1 (0.48) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL28845467 0.87 ALDH1A1 (0.47) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL9330660 0.85 CYP3A4 (0.41) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL7714905 0.81 ALDH1A1 (0.34) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL8749954 0.80 L3MBTL1 (0.39) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL360294 0.80 L3MBTL1 (0.39) ALDH1A1CYP3A4TDP1MAPTCYP1A2
Ammonia Solution, Strong SCHEMBL302065 0.80 ALDH1A1 (0.33) ALDH1A1CYP3A4TDP1MAPTCYP1A2
SCHEMBL31260548 0.79 ALDH1A1 (0.44) ALDH1A1CYP3A4TDP1MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1892259-B1 Hole transport polymers DU PONT (US) 2009-10-07 EP disclosed
EP-2069419-A2 HOLE TRANSPORT POLYMERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2009-06-17 EP disclosed
WO-2008024378-A2 HOLE TRANSPORT POLYMERS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-02-28 WO disclosed
EP-1892259-A1 Hole transport polymers E.I.Du pont de nemours and company (US) 2008-02-27 EP disclosed