Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.46 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | USP36 | Q9P275 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835041 | 0.83 | IMPDH2 (0.45) | IMPDH2B3GNT2ROCK2ROCK1PPARG | |
| SCHEMBL3040156 | 0.82 | IMPDH2 (0.54) | IMPDH2ROCK2ROCK1CYP1A2CYP2C9 | |
| SCHEMBL3836090 | 0.81 | ROCK2 (0.42) | IMPDH2B3GNT2ROCK2ROCK1HDAC1 | |
| SCHEMBL3046619 | 0.81 | IMPDH2 (0.51) | IMPDH2ROCK2ROCK1PPARGUSP36 | |
| SCHEMBL3049695 | 0.79 | IMPDH2 (0.52) | IMPDH2ROCK2ROCK1PPARGMEN1 | |
| SCHEMBL3039346 | 0.76 | ROCK2 (0.57) | IMPDH2ROCK2ROCK1CYP1A2CYP2C19 | |
| SCHEMBL3836791 | 0.76 | IMPDH2 (0.49) | IMPDH2B3GNT2ROCK2ROCK1HDAC1 | |
| SCHEMBL3835811 | 0.74 | POLB (0.56) | IMPDH2B3GNT2ROCK2USP36CYP1A2 | |
| SCHEMBL3046746 | 0.73 | VNN1 (0.57) | IMPDH2USP36CYP2C19MEN1KMT2A | |
| SCHEMBL3039120 | 0.72 | POLB (0.58) | IMPDH2ROCK2ROCK1HDAC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |