Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14698064 | 0.82 | KMT2A (0.54) | MEN1NPC1KMT2ASNCAPOLB | |
| SCHEMBL16667889 | 0.73 | KMT2A (0.43) | MEN1NPC1KMT2ASNCAALDH1A1 | |
| SCHEMBL31393776 | 0.71 | KMT2A (0.57) | MEN1NPC1KMT2ASNCACA1 | |
| SCHEMBL29368910 | 0.71 | CA2 (0.45) | MEN1NPC1KMT2ASNCACA1 | |
| SCHEMBL9550491 | 0.71 | PARP15 (0.46) | MEN1NPC1KMT2ACA1CA2 | |
| SCHEMBL1705319 | 0.71 | CA2 (0.45) | CA1CA2ALDH1A1MAPTMMP2 | |
| SCHEMBL1925493 | 0.70 | NPC1 (0.73) | MEN1NPC1KMT2ASNCAPOLB | |
| SCHEMBL2112731 | 0.69 | KMT2A (0.63) | MEN1NPC1KMT2ASNCACA1 | |
| SCHEMBL7341997 | 0.69 | NPC1 (0.71) | MEN1NPC1KMT2ASNCAPOLB | |
| SCHEMBL1081803 | 0.69 | NPSR1 (0.41) | MEN1NPC1KMT2APOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220091-A2 | REVERSE TRANSCRIPTASE INHIBITORS | Ardea Biosciences, Inc. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009079412-A2 | REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2009-06-25 | — | — | WO | disclosed |