Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | HTT | P42858 | 4/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | MITF | O75030 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345303 | 0.84 | ALDH1A1 (1.00) | NPC1RAB9AALDH1A1KMT2AHTT | |
| SCHEMBL14698064 | 0.81 | KMT2A (0.54) | NPC1RAB9AALDH1A1KMT2AHTT | |
| SCHEMBL21800131 | 0.81 | KMT2A (0.51) | NPC1RAB9AALDH1A1KMT2AHTT | |
| SCHEMBL7339289 | 0.78 | RAB9A (0.79) | NPC1RAB9AALDH1A1KMT2AHTT | |
| SCHEMBL31393776 | 0.77 | KMT2A (0.57) | NPC1RAB9AALDH1A1KMT2ANPSR1 | |
| SCHEMBL31074337 | 0.77 | FNIP1 (0.60) | NPC1RAB9AALDH1A1KMT2AHTT | |
| SCHEMBL27534539 | 0.75 | KMT2A (0.49) | NPC1ALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL2112731 | 0.75 | KMT2A (0.63) | NPC1ALDH1A1KMT2ANPSR1MEN1 | |
| SCHEMBL7338508 | 0.74 | NPC1 (0.71) | NPC1RAB9AALDH1A1KMT2AHTT | |
| SCHEMBL7339671 | 0.74 | CACNA2D1 (0.53) | NPC1RAB9AALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0585500-A1 | Diaryl piperazineacetamides as antimuscarinic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-09 | — | — | EP | disclosed |