Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3051382 | 0.92 | NR1H2 (0.36) | NR1H2NR1H3TBK1CXCR4BRD4 | |
| SCHEMBL3037479 | 0.92 | NR1H2 (0.35) | NR1H2NR1H3TBK1CXCR4BRD4 | |
| SCHEMBL3034089 | 0.92 | NR1H2 (0.35) | NR1H2NR1H3TBK1CXCR4BRD4 | |
| SCHEMBL3044249 | 0.91 | NR1H2 (0.35) | NR1H2NR1H3TBK1CXCR4BRD4 | |
| SCHEMBL3051443 | 0.91 | TBK1 (0.36) | NR1H2NR1H3TBK1CXCR4BRD4 | |
| SCHEMBL3037182 | 0.90 | ACHE (0.37) | NR1H2TBK1CHEK1SMN1; SMN2 | |
| SCHEMBL3048520 | 0.90 | NR1H2 (0.38) | NR1H2NR1H3TBK1BRD4CREBBP | |
| SCHEMBL3051369 | 0.89 | NR1H2 (0.39) | NR1H2NR1H3BRD4CREBBP | |
| SCHEMBL3046133 | 0.89 | NR1H2 (0.34) | NR1H2NR1H3TBK1CXCR4BRD4 | |
| SCHEMBL5050607 | 0.89 | NR1H2 (0.37) | NR1H2NR1H3TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |