Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | DHODH | Q02127 | 4/20 | 0.49 |
| ▸ | KMO | O15229 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986666 | 0.87 | DHODH (0.50) | DHODHHDAC4CTRC | |
| SCHEMBL6166963 | 0.86 | KMO (0.53) | SCN9AKMOHDAC4 | |
| SCHEMBL14564377 | 0.82 | SCN9A (0.62) | SCN9AKMOEGFRHDAC4 | |
| SCHEMBL4266117 | 0.78 | KMO (0.75) | DHODHKMOEGFRCTRC | |
| SCHEMBL4765377 | 0.77 | HDAC4 (0.50) | HDAC4LDHALOXL2 | |
| SCHEMBL27607302 | 0.76 | HDAC4 (0.51) | SCN9AHDAC4CTRC | |
| SCHEMBL648786 | 0.76 | SCN9A (0.53) | SCN9AHDAC4 | |
| SCHEMBL28462472 | 0.76 | DHODH (0.75) | DHODHKMOEGFRCTRC | |
| Hydrochloric Acid SCHEMBL28453167 | 0.74 | DHODH (0.72) | DHODHKMOEGFRCTRC | |
| SCHEMBL1768904 | 0.74 | DHODH (0.77) | DHODHKMOEGFRCTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091927-A1 | THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-Roche AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008055840-A1 | THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |