SCHEMBL648786

SCHEMBL648786

c1ccc(-c2cocn2)cc1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.53
HDAC4 P56524 1/20 0.50
RAB9A P51151 2/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
IMPDH2 P12268 2/20 0.39
EDNRB P24530 1/20 0.39
EDNRA P25101 1/20 0.39
NPC1 O15118 1/20 0.39
FAAH O00519 1/20 0.38
ASIC3 Q9UHC3 2/20 0.38
ADORA2A P29274 2/20 0.38
MIF P14174 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
AURKA O14965 1/20 0.38
HSP90AA1 P07900 1/20 0.38
PRKACA P17612 1/20 0.38
ADORA1 P30542 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27607302 0.96 HDAC4 (0.51) SCN9AHDAC4RAB9AMEN1KMT2A
SCHEMBL14564377 0.86 SCN9A (0.62) SCN9AHDAC4IMPDH2
SCHEMBL16159514 0.85 HDAC4 (0.45) SCN9AHDAC4RAB9AMEN1KMT2A
SCHEMBL16159726 0.81 HDAC4 (0.44) SCN9AHDAC4IMPDH2EDNRBEDNRA
SCHEMBL16159513 0.81 SCN9A (0.46) SCN9AHDAC4IMPDH2EDNRBEDNRA
SCHEMBL1646144 0.81 ALDH1A1 (0.50) HDAC4RAB9AMEN1KMT2ANPC1
SCHEMBL16159199 0.80 HDAC4 (0.43) SCN9AHDAC4IMPDH2EDNRBEDNRA
SCHEMBL16159200 0.80 SCN9A (0.45) SCN9AHDAC4IMPDH2EDNRBEDNRA
SCHEMBL3193030 0.79 LMNA (0.43) SCN9AHDAC4RAB9ANPC1ADORA2A
SCHEMBL16159201 0.79 SCN9A (0.45) SCN9AHDAC4IMPDH2EDNRBEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 880 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120040505-A Phosphorus phenol ligand, phosphorus phenol complex, preparation method and application thereof, and ethylene polymerization method 南开大学 2025-05-27 CN claimed
CN-114920719-A Preparation method of 3-furfural 湖南华腾制药有限公司 2022-08-19 CN claimed
EP-3019477-B1 HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2021-05-26 EP claimed
CN-107011336-A One class is using pyridine as the pH fluorescence probes and its application for protonating site 同济大学 2017-08-04 CN claimed
US-9714224-B2 Heterocyclic compounds and methods of their use NOVARTIS AG (CH) 2017-07-25 US claimed
US-20160145213-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE SPINIFEX PHARMACEUTICALS PTY LTD (AU) 2016-05-26 US claimed
EP-3019477-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE Novartis AG (CH) 2016-05-18 EP claimed
WO-2015003223-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE SPINIFEX PHARMACEUTICALS PTY LTD (AU) 2015-01-15 WO claimed
EP-0699192-A1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-03-06 EP claimed
WO-1994027980-A1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1994-12-08 WO claimed
US-5142545-A LASER DYE LAMBDA PHYSIK GESELLSCHAFT ZUR HERSTELLUNG VON LASERN MBH (DE) 1992-08-25 US claimed
US-4925901-A STORAGE STAABILITY, ONIUM ION CATALYST THE DOW CHEMICAL COMPANY (US) 1990-05-15 US claimed
US-4891305-A LASERS RICOH CO., LTD. (JP) 1990-01-02 US claimed
US-4102688-A CONTAINING PYRAZOLO(3,4-B)PYRIDINE/3,6-DIONE MOIETY FUJI PHOTO FILM CO., LTD. (JP) 1978-07-25 US claimed
US-3977880-A Direct-positive emulsion containing silver halide grains internally doped with metal ions, surface ripened with gold and sulfur compound and fogged by light exposure FUJI PHOTO FILM CO., LTD. (JA) 1976-08-31 US claimed
US-3970461-A Fogged, direct-positive silver halide emulsion containing carbocyanine dye having indolenine nucleus FUJI PHOTO FILM CO., LTD. (JA) 1976-07-20 US claimed
EP-4725942-A1 COMPOUNDS ACTIVE ON CYCLIN D1 PATHWAY AND THEIR USE Sibylla Biotech S.p.A. (IT) 2026-04-15 EP disclosed
US-12595244-B2 Small molecule inhibitors of mammalian SLC6A19 function JNANA THERAPEUTICS INC. (US) 2026-04-07 US disclosed
US-3935010-A IMIDAZOQUINOXALINE DESENSITIZER EASTMAN KODAK COMPANY (US) 1976-01-27 US disclosed
US-3933507-A LIGHT INSENSITIVE SILVER SALT, POLYMETHINE SENSITIZER AGFA-GEVAERT, A.G. (DT) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12595244-B2 Small molecule inhibitors of mammalian SLC6A19 function SLC6A19, SLC6A15, SLC19A1 SCN9A 125/4885HDAC4 2129/4885RAB9A 747/4885
US-20160145213-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE AGTR2, AGTR1, AGT SCN9A 4177/4885HDAC4 2572/4885RAB9A 3785/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.