Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CCL2 | P13500 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15744464 | 0.82 | MEN1 (0.40) | LMNAALDH1A1HSD17B10SMN1; SMN2TDP1 | |
| SCHEMBL3312303 | 0.77 | BRD4 (0.39) | MAOAMAOBBRD4CCL2LMNA | |
| SCHEMBL4235647 | 0.74 | BRD4 (0.43) | MAOAMAOBBRD4CCL2LMNA | |
| SCHEMBL7006425 | 0.68 | BRD4 (0.38) | BRD4CCL2LMNADRD2DRD4 | |
| Maleic Acid SCHEMBL28893513 | 0.68 | ALDH1A1 (0.42) | BRD4CCL2LMNAALDH1A1SMN1; SMN2 | |
| Pivalate SCHEMBL7596893 | 0.67 | ALDH1A1 (0.34) | BRD4CCL2LMNADRD2DRD4 | |
| SCHEMBL9205811 | 0.66 | BRD4 (0.50) | BRD4CCL2LMNADRD2DRD4 | |
| SCHEMBL13519456 | 0.66 | LMNA (0.38) | MAOAMAOBBRD4LMNAALDH1A1 | |
| SCHEMBL503745 | 0.65 | MAOA (0.50) | MAOAMAOBLMNAALDH1A1TDP1 | |
| SCHEMBL30895284 | 0.65 | MAOA (0.50) | MAOAMAOBLMNAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111399-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008076427-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |