SCHEMBL384076

SCHEMBL384076

Nc1nc2ccccc2nc1-c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.61
ALDH1A1 P00352 7/20 0.61
GAA P10253 4/20 0.61
HPGD P15428 3/20 0.61
HSD17B10 Q99714 2/20 0.61
MAPT P10636 2/20 0.61
PKM P14618 2/20 0.57
KMT2A Q03164 4/20 0.57
ATM Q13315 2/20 0.57
TLR9 Q9NR96 1/20 0.57
LMNA P02545 6/20 0.55
L3MBTL1 Q9Y468 4/20 0.55
TDP1 Q9NUW8 3/20 0.55
MEN1 O00255 3/20 0.55
CSNK1A1 P48729 1/20 0.55
CLK4 Q9HAZ1 1/20 0.55
ADORA2A P29274 2/20 0.53
NUDT1 P36639 1/20 0.53
GLA P06280 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29215313 0.87 KDM4E (0.56) KDM4EALDH1A1GAAHPGDHSD17B10
SCHEMBL31448436 0.84 TDP1 (0.69) KDM4EALDH1A1GAAHPGDHSD17B10
SCHEMBL29382173 0.83 KDM4E (0.74) KDM4EALDH1A1GAAHPGDMAPT
SCHEMBL732131 0.83 KDM4E (0.74) KDM4EALDH1A1GAAHPGDMAPT
SCHEMBL23173620 0.81 CSNK1A1 (0.59) KDM4EALDH1A1GAAHPGDHSD17B10
SCHEMBL865711 0.80 KDM4E (0.71) KDM4EALDH1A1GAAHPGDMAPT
SCHEMBL28710728 0.80 KDM4E (0.71) KDM4EALDH1A1GAAHPGDMAPT
SCHEMBL13950894 0.80 KDM4E (0.78) KDM4EALDH1A1GAAHPGDMAPT
Water SCHEMBL27680271 0.80 KDM4E (0.71) KDM4EALDH1A1GAAHPGDMAPT
SCHEMBL23384670 0.80 KMT2A (0.71) KDM4EALDH1A1GAAHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999042463-A1 SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1999-08-26 WO claimed
WO-1999042461-A1 SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1999-08-26 WO claimed
US-20230301984-A1 CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-09-28 US disclosed
EP-4225006-A2 ORGANIC LIGHT-EMITTING DEVICE Samsung Display Co., Ltd. (KR) 2023-08-09 EP disclosed
WO-2023124205-A1 ORGANIC COMPOUNDS, ORGANIC ELECTROLUMINESCENT DEVICE AND ELECTRONIC APPARATUS 陕西莱特光电材料股份有限公司 2023-07-06 WO disclosed
EP-3246963-B1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO LTD (KR) 2023-05-31 EP disclosed
US-20220029108-A1 ORGANIC ELECTROLUMINESCENT COMPOUND, A PLURALITY OF HOST MATERIALS AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME DUPONT SPECIALTY MATERIALS KOREA LTD. (KR) 2022-01-27 US disclosed
EP-3246963-A2 ORGANIC LIGHT-EMITTING DEVICE Samsung Display Co., Ltd. (KR) 2017-11-22 EP disclosed
EP-2408744-A1 BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE Schering Corporation (US) 2012-01-25 EP disclosed
JP-2005314624-A HIGH-STRENGTH EPOXY RESIN CHIBA UNIV 2005-11-10 JP disclosed
JP-2005298788-A HEAT-RESISTANT AND HIGH STRENGTH EPOXY RESIN CHIBA UNIV 2005-10-27 JP disclosed
JP-2005060481-A HEAT RESISTANT EPOXY HARDENER CHIBA UNIV 2005-03-10 JP disclosed
US-6548499-B1 N-(1-Azabicyclo(2.2.2)octanyl-3-pyridinyl)-3-(2-pyridinyl)-2 -quinoxalinamine, for example; treating various chemokine mediated diseases MILLENNIUM PHARMACEUTICALS, INC. 2003-04-15 US disclosed
WO-1999042463-A1 SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1999-08-26 WO disclosed
WO-1999042461-A1 SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1999-08-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230301984-A1 CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION ALDH1A2, PDE6D, PDE6C KDM4E 3316/4885ALDH1A1 145/4885GAA 359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.