Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 6/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837565 | 0.90 | PTGES (0.46) | PTGESFFAR1CYP2D6HRH3DRD2 | |
| SCHEMBL3859050 | 0.87 | CA12 (0.47) | PTGESFFAR1KCNH2 | |
| SCHEMBL3841194 | 0.87 | FFAR1 (0.44) | PTGESFFAR1CYP2D6HRH3DRD2 | |
| SCHEMBL3859573 | 0.86 | PTGES (0.44) | PTGESFFAR1CYP2D6HRH3 | |
| SCHEMBL3864253 | 0.84 | ASIC3 (0.47) | PTGESFFAR1ASIC3 | |
| SCHEMBL3843357 | 0.84 | GRM5 (0.48) | PTGESFFAR1CYP2D6HRH3DRD2 | |
| SCHEMBL27874223 | 0.84 | TP53 (0.52) | PTGESFFAR1CYP2D6HRH3APP | |
| SCHEMBL3839454 | 0.83 | FFAR1 (0.47) | PTGESFFAR1CYP2D6HRH3 | |
| SCHEMBL3859036 | 0.82 | FFAR1 (0.47) | PTGESFFAR1CYP2D6HRH3DRD2 | |
| SCHEMBL2833040 | 0.82 | FFAR1 (0.58) | FFAR1APPASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |