Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | IDH2 | P48735 | 3/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | PHGDH | O43175 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889336 | 0.80 | BRAF (0.70) | BRAFRAF1KDR | |
| SCHEMBL6204462 | 0.78 | BRAF (0.72) | BRAFRAF1KDR | |
| SCHEMBL4976784 | 0.76 | KIF11 (0.50) | BRAFIDH2RAF1KDRMAPT | |
| SCHEMBL12413883 | 0.75 | HDAC6 (0.49) | GAABRAFRAF1KDRNPC1 | |
| SCHEMBL13788619 | 0.75 | BRAF (0.73) | BRAFRAF1KDR | |
| SCHEMBL2352223 | 0.75 | DYRK1A (0.52) | GAAPHGDH | |
| SCHEMBL17432160 | 0.75 | ABCG2 (0.65) | GAAIDH2RAB9AMAPTTP53 | |
| SCHEMBL22507230 | 0.75 | MEN1 (0.54) | GAAPHGDHNPC1RAB9AMAPT | |
| SCHEMBL17661777 | 0.74 | RAB9A (0.68) | GAANPC1RAB9AMAPTTP53 | |
| SCHEMBL14882044 | 0.73 | GAA (0.58) | GAANPC1RAB9AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |