Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837370 | 0.82 | TAAR1 (0.41) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL5477922 | 0.81 | TAAR1 (0.61) | TRPA1TAAR1 | |
| SCHEMBL3228373 | 0.81 | TAAR1 (0.51) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL13862448 | 0.77 | TAAR1 (0.45) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL611119 | 0.77 | TAAR1 (0.45) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL13463064 | 0.76 | KDM4E (0.58) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL3836970 | 0.75 | GGPS1 (0.42) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL4329313 | 0.75 | TAAR1 (0.41) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL3842023 | 0.75 | MAPK1 (0.43) | TAAR1MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL3842349 | 0.74 | TRPA1 (0.54) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |