Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 2/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287473 | 0.84 | NOS1 (0.39) | ADRB2NOS1NOS2PNMTPGK1 | |
| SCHEMBL17277380 | 0.81 | CYP3A4 (0.41) | NOS1NOS2LMNAPNMTPGK1 | |
| SCHEMBL612758 | 0.77 | NOS1 (0.40) | NOS1NOS2PNMTPGK1PGK2 | |
| SCHEMBL611386 | 0.76 | NOS1 (0.33) | ADRB2NOS1NOS2PNMT | |
| SCHEMBL13959620 | 0.76 | PRSS1 (0.41) | ADRB2NOS1NOS2PNMTPGK1 | |
| SCHEMBL14642896 | 0.75 | LPL (0.42) | NOS1NOS2 | |
| SCHEMBL3839058 | 0.75 | NOS1 (0.38) | NOS1NOS2PNMT | |
| SCHEMBL610891 | 0.74 | GRIN2D (0.40) | NOS1NOS2LMNAPNMT | |
| SCHEMBL27836303 | 0.74 | PNMT (0.39) | ADRB2NOS1NOS2LMNAPNMT | |
| SCHEMBL28043377 | 0.74 | PGK1 (0.42) | NOS1NOS2PNMTPGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |