Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243792 | 0.97 | HDAC1 (0.63) | HDAC1HDAC8KMT2AMEN1L3MBTL1 | |
| SCHEMBL25169970 | 0.95 | HDAC1 (0.66) | HDAC1HDAC8KMT2AMEN1L3MBTL1 | |
| SCHEMBL7398 | 0.89 | KMT2A (0.64) | HDAC1HDAC8KMT2AMEN1L3MBTL1 | |
| SCHEMBL7925389 | 0.85 | KMT2A (0.59) | HDAC1HDAC8KMT2AMEN1L3MBTL1 | |
| SCHEMBL14982196 | 0.85 | KMT2A (0.52) | HDAC1HDAC8KMT2AMEN1L3MBTL1 | |
| SCHEMBL28440147 | 0.84 | PDE4B (0.56) | HDAC1HDAC8KMT2AL3MBTL1MAPT | |
| SCHEMBL14842796 | 0.83 | KMT2A (0.65) | HDAC1HDAC8KMT2AMEN1L3MBTL1 | |
| SCHEMBL9541227 | 0.83 | PDE4B (0.73) | HDAC1HDAC8KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL1533298 | 0.83 | NPC1 (0.72) | KMT2AMEN1L3MBTL1ALDH1A1TSHR | |
| SCHEMBL7467309 | 0.83 | TSHR (0.52) | KMT2AMEN1L3MBTL1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432700-B1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-04 | — | — | EP | disclosed |
| US-7078420-B2 | Spiro-hydantoin compounds useful as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-18 | — | — | US | disclosed |
| US-6977267-B2 | Spiro-hydantoin compounds useful as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-20 | — | — | US | disclosed |
| CN-1596253-A | Spiro-hydantoin compounds useful as anti-inflammatory agents | BRISTOL MYERS SQUIBB CO (US) | 2005-03-16 | — | — | CN | disclosed |
| US-20050004153-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | DHAR T G MURALI (US) | 2005-01-06 | — | — | US | disclosed |
| US-20040259897-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | DHAR T G MURALI (US) | 2004-12-23 | — | — | US | disclosed |
| EP-1432700-A4 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-22 | — | — | EP | disclosed |
| US-20040248920-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | DHAR T G MURALI (US) | 2004-12-09 | — | — | US | disclosed |
| EP-1432700-A1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | Bristol-Myers Squibb Company (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20040009998-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | CEREP SA (FR) | 2004-01-15 | — | — | US | disclosed |
| WO-2003029245-A1 | SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259897-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | ICAM1, VCAM1, SELL | HDAC1 33/4885HDAC8 216/4885KMT2A 1504/4885 |
| US-20040248920-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | ICAM1, VCAM1, SELL | HDAC1 33/4885HDAC8 216/4885KMT2A 1504/4885 |
| US-20040009998-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | ICAM1, VCAM1, SELL | HDAC1 33/4885HDAC8 211/4885KMT2A 1444/4885 |
| US-20050004153-A1 | Spiro-hydantoin compounds useful as anti-inflammatory agents | ICAM1, VCAM1, ITGA4 | HDAC1 60/4885HDAC8 317/4885KMT2A 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.