SCHEMBL384207

SCHEMBL384207

COC(=O)c1cc(Cn2nc(C(F)(F)F)cc2C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.39
GRIN1 Q05586 1/20 0.36
GRIN2A Q12879 1/20 0.36
DHODH Q02127 1/20 0.35
STIM1 Q13586 1/20 0.35
ORAI1 Q96D31 1/20 0.35
OPRL1 P41146 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
TRPA1 O75762 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
SLC16A3 O15427 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL385572 0.89 KDM4E (0.44) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL384545 0.89 KDM4E (0.42) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL4343369 0.86 KDM4E (0.40) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15489004 0.84 DHODH (0.34) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL15862865 0.83 DHODH (0.36) DHODHTRPA1TRPV1SLC16A3SLC16A1
SCHEMBL21636814 0.83 KDM4E (0.45) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL4349665 0.83 KDM4E (0.40) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL4346448 0.83 KDM4E (0.40) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL16014672 0.80 MALT1 (0.37) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL2623668 0.80 DHODH (0.36) ALDH1A1DHODHTRPA1TRPV1SLC16A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10849878-B2 Agent exhibiting anti-stress, anxiolytic and anti-depression activity, and composition based thereon OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU “NORMOFARM” (RU) 2020-12-01 US disclosed
US-10456373-B2 Agent exhibiting anti-stress, anxiolytic and anti-depression activity, and composition based thereon OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU “NORMOFARM” (RU) 2019-10-29 US disclosed
US-8946236-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2015-02-03 US disclosed
CN-103896891-A Ascorbic acid lithium and preparation method thereof LI YUCHENG 2014-07-02 CN disclosed
CN-101466702-B Anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents BAYER CROPSCIENCE AG 2014-04-02 CN disclosed
US-8609169-B2 Methods for preserving fresh produce NATURESEAL, INC. (US) 2013-12-17 US disclosed
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2013-12-05 US disclosed
US-20130309380-A1 METHODS FOR PRESERVING FRESH PRODUCE NATURESEAL, INC. (US) 2013-11-21 US disclosed
US-8536092-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-20120201939-A1 Methods for Preserving Fresh Produce MANTROSE-HAEUSER CO., INC. (US) 2012-08-09 US disclosed
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2012-04-19 US disclosed
US-8101550-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2012-01-24 US disclosed
US-8101221-B2 Extends shelf life while preserving texture, flavor, appearance, crispness, and color; comprises strontium/lithium/barium/aluminum/copper/iron/manganese ascorbate/erythorbate MANTROSE-HAEUSER CO., INC. (US) 2012-01-24 US disclosed
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-02-04 US disclosed
EP-1659887-B1 METHODS FOR PRESERVING FRESH PRODUCE MANTROSE HAEUSER CO INC (US) 2009-04-15 EP disclosed
EP-1659887-A4 METHODS FOR PRESERVING FRESH PRODUCE MANTROSE HAEUSER CO INC (US) 2007-05-02 EP disclosed
EP-1659887-A1 METHODS FOR PRESERVING FRESH PRODUCE Mantrose-Haeuser Co. Inc. (US) 2006-05-31 EP disclosed
US-20050084602-A1 Methods for preserving fresh produce MANTROSE-HAEUSER CO., INC. 2005-04-21 US disclosed
WO-2005023022-A1 METHODS FOR PRESERVING FRESH PRODUCE MANTROSE-HAEUSER CO., INC. (US) 2005-03-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KDM4E 1199/4885MEN1 1727/4885ALDH1A1 2028/4885
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KDM4E 1199/4885MEN1 1727/4885ALDH1A1 2028/4885
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KDM4E 1199/4885MEN1 1727/4885ALDH1A1 2028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.