SCHEMBL384545

SCHEMBL384545

O=C(O)c1cc(Cn2nc(C(F)(F)F)cc2C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
MAPT P10636 1/20 0.42
KMT2A Q03164 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
KLKB1 P03952 2/20 0.38
GRIN1 Q05586 2/20 0.36
GRIN2A Q12879 2/20 0.36
MARS1 P56192 1/20 0.35
GRN P28799 2/20 0.35
SORT1 Q99523 2/20 0.35
RORC P51449 1/20 0.35
TRPA1 O75762 2/20 0.34
NPC1 O15118 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
SLC16A3 O15427 1/20 0.33
SLC16A1 P53985 1/20 0.33
OPRL1 P41146 1/20 0.33
STIM1 Q13586 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL385572 0.92 KDM4E (0.44) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL384207 0.89 KDM4E (0.41) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL4349665 0.86 KDM4E (0.40) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL4346448 0.84 KDM4E (0.40) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL21636814 0.84 KDM4E (0.45) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL535347 0.83 KLKB1 (0.49) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL24950074 0.82 OPRL1 (0.36) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL30206510 0.82 OPRL1 (0.36) KDM4EMEN1ALDH1A1MAPTKMT2A
Hydrochloric Acid SCHEMBL536232 0.82 KLKB1 (0.48) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL4343369 0.82 KDM4E (0.40) KDM4EMEN1ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020016841-A1 A NOVEL PROCESS FOR THE PREPARATION OF ANTHRANILIC DIAMIDES PI INDUSTRIES LTD. (IN) 2020-01-23 WO disclosed
US-8946236-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2015-02-03 US disclosed
US-8946236-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2015-02-03 US disclosed
US-8946236-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2015-02-03 US disclosed
CN-101466702-B Anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents BAYER CROPSCIENCE AG 2014-04-02 CN disclosed
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2013-12-05 US disclosed
US-8536092-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-8536092-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2012-04-19 US disclosed
US-8101550-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2012-01-24 US disclosed
US-8101550-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2012-01-24 US disclosed
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-02-04 US disclosed
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-02-04 US disclosed
CN-101466702-A Anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents BAYER CROPSCIENCE AG (DE) 2009-06-24 CN disclosed
WO-2007144100-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2007-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KDM4E 1199/4885MEN1 1727/4885ALDH1A1 2028/4885
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KDM4E 1199/4885MEN1 1727/4885ALDH1A1 2028/4885
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KDM4E 1199/4885MEN1 1727/4885ALDH1A1 2028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.