Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842300 | 1.00 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1GRM4RAB9A | |
| SCHEMBL4464910 | 0.91 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL4464904 | 0.91 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL1793434 | 0.88 | PRMT1 (0.45) | LMNASMN1; SMN2ALDH1A1GRM4MET | |
| SCHEMBL2928469 | 0.86 | MET (0.49) | METAXLPDGFRAKDRRET | |
| SCHEMBL2928468 | 0.86 | MET (0.49) | METAXLPDGFRAKDRRET | |
| SCHEMBL2937186 | 0.84 | PDGFRA (0.45) | LMNASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL2937189 | 0.84 | PDGFRA (0.45) | LMNASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL1794175 | 0.83 | GRM4 (0.43) | GRM4MAPTMEN1KMT2AMET | |
| SCHEMBL1794794 | 0.82 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013207-A1 | IMIDAZO[4, 5-B]PYRIDIN-2-ONE AND OXAZOLO[4, 5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS | Cancer Research Technology Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007125330-A1 | IMIDAZO[4, 5-B]PYRIDIN-2-ONE AND OXAZOLO[4, 5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |