Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | GYS1 | P13807 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445026 | 0.83 | AHR (0.67) | AHRTSHRHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL9441987 | 0.79 | PIM1 (0.52) | TSHRHSD17B10ALDH1A1CYP3A4PIM1 | |
| SCHEMBL9121522 | 0.79 | AHR (0.56) | AHRTSHRHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL6242615 | 0.78 | HSD17B10 (0.62) | TSHRHSD17B10ALDH1A1CYP3A4TDP1 | |
| SCHEMBL31093991 | 0.78 | HSD17B10 (0.62) | TSHRHSD17B10ALDH1A1CYP3A4TDP1 | |
| SCHEMBL5094107 | 0.78 | ALOX5 (0.62) | TSHRHSD17B10ALDH1A1TDP1TP53 | |
| SCHEMBL7723870 | 0.78 | AHR (0.54) | AHRHSD17B10ALDH1A1PIK3CAPIK3CD | |
| SCHEMBL4447113 | 0.77 | AHR (0.65) | AHRTSHRHSD17B10ALDH1A1TP53 | |
| SCHEMBL15675199 | 0.77 | BIRC5 (0.44) | AHRPIK3CAPIK3CDGYS1PIK3CB | |
| SCHEMBL5088969 | 0.77 | KDM1A (0.51) | AHRPIK3CAPIK3CDGYS1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784388-B3 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| EP-1784388-B1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2009-11-04 | — | — | EP | disclosed |