Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710534 | 0.99 | KDM4E (0.34) | KDM4EALDH1A1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL3839037 | 0.77 | TAAR1 (0.38) | SLC6A4 | |
| SCHEMBL3836805 | 0.76 | TAAR1 (0.38) | SMN1; SMN2SLC6A4 | |
| SCHEMBL3836548 | 0.76 | TAAR1 (0.38) | SMN1; SMN2SLC6A4 | |
| SCHEMBL3836993 | 0.76 | TAAR1 (0.38) | SMN1; SMN2SLC6A4 | |
| SCHEMBL3843230 | 0.74 | TAAR1 (0.38) | — | |
| SCHEMBL1710757 | 0.74 | SLC6A4 (0.32) | SLC6A4 | |
| SCHEMBL1710521 | 0.73 | SLC6A4 (0.33) | SLC6A4 | |
| SCHEMBL1710672 | 0.73 | RORC (0.35) | ALDH1A1SMN1; SMN2GAASLC6A4 | |
| SCHEMBL3389330 | 0.71 | HTR6 (0.39) | ALDH1A1SMN1; SMN2MAPK1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |