Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | STK17B | O94768 | 2/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.37 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846179 | 0.82 | APP (0.38) | APPSTK17BSTK17ACAMKK1AURKB | |
| SCHEMBL15853288 | 0.71 | ATM (0.35) | — | |
| SCHEMBL29628718 | 0.71 | CYP1A2 (0.34) | NQO1NQO2CYP2A6 | |
| SCHEMBL649438 | 0.71 | CYP1A2 (0.34) | NQO1NQO2CYP2A6 | |
| SCHEMBL3842558 | 0.70 | — | — | |
| SCHEMBL15026030 | 0.70 | ADORA2A (0.35) | ADORA2AADORA1 | |
| SCHEMBL10045614 | 0.70 | L3MBTL1 (0.38) | APPPIM2KCNH2 | |
| SCHEMBL793586 | 0.68 | CA12 (0.31) | CA2 | |
| SCHEMBL18405847 | 0.68 | CYP1A2 (0.32) | NQO1CYP2A6 | |
| SCHEMBL845603 | 0.68 | APP (0.63) | APPHSD17B1HSD17B2NQO1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090314997-A1 | SUBSTITUTED BENZODITHIOPHENES AND BENZODISELENOPHENES | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-24 | — | — | US | disclosed |
| US-20090314997-A1 | SUBSTITUTED BENZODITHIOPHENES AND BENZODISELENOPHENES | MERCK PATENT GESELLSCHAFT (DE) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090314997-A1 | SUBSTITUTED BENZODITHIOPHENES AND BENZODISELENOPHENES | TPST2, TST, XPOT | APP 3140/4885STK17B 2244/4885STK17A 1992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.