Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 8/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | APEH | P13798 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843692 | 1.00 | PPME1 (0.41) | PPME1GPR183APEHHDAC3HDAC4 | |
| SCHEMBL24282442 | 0.86 | PPME1 (0.50) | PPME1APEHHDAC3HDAC4HDAC1 | |
| SCHEMBL295226 | 0.80 | HDAC1 (0.42) | GPR183HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL295225 | 0.80 | HDAC1 (0.42) | GPR183HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL299897 | 0.77 | HDAC6 (0.44) | PPME1APEHHDAC3HDAC1HDAC2 | |
| SCHEMBL299898 | 0.77 | HDAC6 (0.44) | PPME1APEHHDAC3HDAC1HDAC2 | |
| SCHEMBL3345694 | 0.72 | HSD17B3 (0.61) | PKM | |
| SCHEMBL2209337 | 0.72 | HSD17B3 (0.61) | PKM | |
| SCHEMBL14874713 | 0.69 | MMP8 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14874714 | 0.69 | MMP8 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861365-B1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2009-07-01 | — | — | EP | disclosed |