Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 19/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 14/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 13/20 | 0.63 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD1 | P21728 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417635 | 0.92 | ADRB2 (0.61) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL3190144 | 0.91 | ADRB2 (0.51) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL3838473 | 0.90 | ADRB2 (0.64) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL775371 | 0.90 | ADRB2 (0.50) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL776477 | 0.88 | ADRB2 (0.49) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL4156334 | 0.87 | ADRB2 (0.82) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL3843365 | 0.87 | ADRB2 (0.82) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL4558207 | 0.86 | ADRB2 (0.46) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL4558208 | 0.86 | ADRB2 (0.46) | ADRB2ADRB1ADRB3DRD2DRD1 | |
| SCHEMBL3840469 | 0.86 | ADRB2 (0.68) | ADRB2ADRB1ADRB3DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641465-B1 | COMBINATIONS OF AN ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONIST AND A CORTICOSTEROID | THERAVANCE INC (US) | 2009-11-04 | — | — | EP | disclosed |
| US-20090227547-A1 | Novel salt form of a Beta2-adrenergic agonist quinolin-2-one derivative | GLAXO GROUP LIMITED (GB) | 2009-09-10 | — | — | US | disclosed |
| US-7582765-B2 | Aryl aniline β2 adrenergic receptor agonists | THERAVANCE, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582765-B2 | Aryl aniline β2 adrenergic receptor agonists | THERAVANCE, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7553971-B2 | Aryl aniline β2 adrenergic receptor agonists | THERAVANCE, INC. (US) | 2009-06-30 | — | — | US | disclosed |
| US-7452995-B2 | Aryl aniline β2 adrenergic receptor agonists | THERAVANCE, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-20070225329-A1 | Aryl aniline beta2 adrenergic receptor agonists | THERAVANCE BIOPHARMA R&D IP, LLC | 2007-09-27 | — | — | US | disclosed |
| US-20070225329-A1 | Aryl aniline beta2 adrenergic receptor agonists | THERAVANCE BIOPHARMA R&D IP, LLC | 2007-09-27 | — | — | US | disclosed |
| EP-1641465-A2 | COMBINATIONS OF AN ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONIST AND A CORTICOSTEROID | Theravance, Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005025555-A2 | COMBINATIONS OF AN ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONIST AND A CORTICOSTEROID | THERAVANCE, INC. (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20030229058-A1 | Aryl aniline beta2 adrenergic receptor agonists | THERAVANCE BIOPHARMA R&D IP, LLC | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227547-A1 | Novel salt form of a Beta2-adrenergic agonist quinolin-2-one derivative | ADRB2, ADRA2B, ADRB1 | ADRB2 1/4885ADRB1 3/4885ADRB3 7/4885 |
| US-20070225329-A1 | Aryl aniline beta2 adrenergic receptor agonists | ADRB2, ADRB3, ADRB1 | ADRB2 1/4885ADRB1 3/4885ADRB3 2/4885 |
| US-20030229058-A1 | Aryl aniline beta2 adrenergic receptor agonists | ADRB2, ADRB1, ADRB3 | ADRB2 1/4885ADRB1 2/4885ADRB3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.