Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SHMT1 | P34896 | 7/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 6/20 | 0.49 |
| ▸ | CDC7 | O00311 | 3/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MARS1 | P56192 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073067 | 0.81 | RAB9A (0.61) | KDM4EMAPTCDC7DBF4RAB9A | |
| SCHEMBL3837371 | 0.80 | KMT2A (0.54) | KDM4EMAPTCDC7DBF4RAB9A | |
| SCHEMBL3413746 | 0.79 | KDM4E (0.65) | KDM4EMAPTSHMT1SHMT2CDC7 | |
| SCHEMBL2076166 | 0.76 | KDM4E (0.56) | KDM4EMAPTSHMT1SHMT2CDC7 | |
| SCHEMBL3436050 | 0.75 | KDM4E (0.44) | KDM4EMAPTSHMT1SHMT2CDC7 | |
| SCHEMBL3435976 | 0.74 | KDM4E (0.48) | KDM4EMAPTSHMT1SHMT2CDC7 | |
| SCHEMBL3837596 | 0.74 | SMN1; SMN2 (0.58) | KDM4EMAPTCDC7DBF4CCNE1 | |
| SCHEMBL10049077 | 0.72 | KDM4E (0.46) | KDM4EMAPTSHMT1SHMT2CDC7 | |
| SCHEMBL18003773 | 0.71 | SHMT1 (0.60) | KDM4EMAPTSHMT1SHMT2CDC7 | |
| SCHEMBL12154280 | 0.70 | RAB9A (0.64) | KDM4EMAPTCDC7DBF4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828207-B1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-10-28 | — | — | EP | disclosed |
| US-20090233919-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233919-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | MCHR1, MCHR2, MC1R | KDM4E 1557/4885MAPT 886/4885SHMT1 1388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.