Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | CDC7 | O00311 | 5/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841307 | 0.87 | TRPM8 (0.47) | SMN1; SMN2CDC7DBF4MAPTGAA | |
| SCHEMBL2073067 | 0.87 | RAB9A (0.61) | SMN1; SMN2CDC7DBF4ALDH1A1MAPT | |
| SCHEMBL12154280 | 0.87 | RAB9A (0.64) | SMN1; SMN2CDC7DBF4ALDH1A1MAPT | |
| SCHEMBL3837371 | 0.85 | KMT2A (0.54) | SMN1; SMN2CDC7DBF4ALDH1A1MAPT | |
| SCHEMBL2073958 | 0.84 | PTGDR2 (0.52) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL3841396 | 0.83 | ALDH1A1 (0.52) | SMN1; SMN2CDC7DBF4ALDH1A1MAPT | |
| SCHEMBL16702679 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2CDC7DBF4ALDH1A1MAPT | |
| SCHEMBL27500256 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2CDC7DBF4ALDH1A1MAPT | |
| SCHEMBL1436076 | 0.78 | RARA (0.50) | SMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL6603353 | 0.75 | L3MBTL1 (0.52) | ALDH1A1MAPTTRPM8KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101080411-B | Thiazolopyridinone derivatives as MCH receptor antagonists | LILLY CO ELI | 2011-11-02 | — | — | CN | disclosed |
| EP-1828207-B1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-10-28 | — | — | EP | disclosed |
| US-20090233919-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2009-09-17 | — | — | US | disclosed |
| CN-101080411-A | Thiazolopyridinone derivatives as MCH receptor antagonists | LILLY CO ELI (US) | 2007-11-28 | — | — | CN | disclosed |
| EP-1828207-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066174-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233919-A1 | THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS | MCHR1, MCHR2, MC1R | SMN1; SMN2 2461/4885CDC7 4085/4885DBF4 4650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.