Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839723 | 0.90 | CCR5 (1.00) | CCR5CHRM2 | |
| SCHEMBL13647739 | 0.80 | CCR5 (1.00) | CCR5KCNH2 | |
| SCHEMBL12796129 | 0.80 | CCR5 (0.71) | CCR5KCNH2CHRM2 | |
| SCHEMBL4391760 | 0.79 | CCR5 (1.00) | CCR5KCNH2CHRM2 | |
| SCHEMBL3843999 | 0.78 | CCR5 (0.64) | CCR5 | |
| SCHEMBL16503431 | 0.77 | CCR5 (0.92) | CCR5KCNH2 | |
| SCHEMBL3841444 | 0.76 | CCR5 (0.61) | CCR5KCNH2CHRM2 | |
| SCHEMBL3841540 | 0.76 | CCR5 (1.00) | CCR5KCNH2 | |
| SCHEMBL12207058 | 0.76 | CCR5 (0.90) | CCR5KCNH2 | |
| SCHEMBL4387384 | 0.75 | CCR5 (1.00) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551827-B1 | PIPERIDINE DERIVATIVES AS CCR5 INHIBITORS | NOVARTIS AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| EP-1379504-B1 | BIPIPERIDINYL-DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTORS INHIBITORS | NOVARTIS PHARMA GMBH (AT) | 2009-10-28 | — | — | EP | disclosed |
| US-20080249111-A1 | Piperdine Derivatives as CCR5 Inhibitors | NOVARTIS AG | 2008-10-09 | — | — | US | disclosed |
| US-7399771-B2 | Piperidine derivatives as CCR5 inhibitors | NOVARTIS AG (CH) | 2008-07-15 | — | — | US | disclosed |
| US-20060004047-A1 | Piperidine derivatives as ccr5 inhibitors | NOVARTIS AG (CH) | 2006-01-05 | — | — | US | disclosed |
| EP-1551827-A1 | PIPERIDINE DERIVATIVES AS CCR5 INHIBITORS | Novartis AG (CH) | 2005-07-13 | — | — | EP | disclosed |
| US-20040142920-A1 | Bipiperidinyl-derivatives and their use as chemokine receptors inhibitors | NOVARTIS | 2004-07-22 | — | — | US | disclosed |
| WO-2004031172-A1 | PIPERIDINE DERIVATIVES AS CCR5 INHIBITORS | NOVARTIS AG (CH) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004047-A1 | Piperidine derivatives as ccr5 inhibitors | CCR5, CCR2, CCR1 | CCR5 1/4885KCNH2 2183/4885CHRM2 337/4885 |
| US-20040142920-A1 | Bipiperidinyl-derivatives and their use as chemokine receptors inhibitors | CCR5, CCR2, CXCR3 | CCR5 1/4885KCNH2 4158/4885CHRM2 1461/4885 |
| US-20080249111-A1 | Piperdine Derivatives as CCR5 Inhibitors | CCR5, CCR2, CCR1 | CCR5 1/4885KCNH2 2095/4885CHRM2 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.