Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.37 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | DDO | Q99489 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050047 | 0.77 | KCNH2 (0.35) | PARP1TNK1MPOKDM4EPARP2 | |
| SCHEMBL3846941 | 0.76 | KCNH2 (0.47) | PARP1DAODDOMPOKDM4E | |
| SCHEMBL5047695 | 0.72 | PARP1 (0.38) | PARP1TNK1PARP2 | |
| SCHEMBL3844362 | 0.72 | KCNH2 (0.37) | KDM4E | |
| SCHEMBL5047640 | 0.72 | MPO (0.36) | PARP1MPOKDM4E | |
| SCHEMBL5050024 | 0.70 | MPO (0.35) | PARP1MPOKDM4EPARP2 | |
| SCHEMBL3847249 | 0.70 | HRH4 (0.42) | PARP1DAODDOMPOKDM4E | |
| SCHEMBL3846224 | 0.68 | PARP1 (0.46) | PARP1KDM4E | |
| SCHEMBL2126317 | 0.67 | KDM5A (0.57) | PARP1DAODDOKDM4EFEN1 | |
| SCHEMBL4770655 | 0.65 | KCNH2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |