Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 7/20 | 0.34 |
| ▸ | HTR2C | P28335 | 6/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050024 | 0.88 | MPO (0.35) | MPOKCNH2PARP1HTR2AHTR2C | |
| SCHEMBL5050047 | 0.85 | KCNH2 (0.35) | MPOKCNH2PARP1HTR2AHTR2C | |
| SCHEMBL5047695 | 0.85 | PARP1 (0.38) | KCNH2PARP1HTR2AHTR2CDRD2 | |
| SCHEMBL3846941 | 0.81 | KCNH2 (0.47) | MPOKCNH2PARP1HTR2AHTR2C | |
| SCHEMBL5047576 | 0.77 | EGLN1 (0.37) | KCNH2PARP1HTR2AHTR2CSLC6A2 | |
| SCHEMBL3844281 | 0.72 | PARP1 (0.37) | MPOPARP1KDM4E | |
| SCHEMBL4425807 | 0.72 | GPR17 (0.52) | PARP1CNR1 | |
| SCHEMBL5047668 | 0.72 | HSD17B10 (0.35) | KCNH2PARP1HTR2AHTR2CSLC6A2 | |
| SCHEMBL5051229 | 0.71 | MPO (0.34) | MPOKCNH2PARP1HTR2ASLC6A2 | |
| SCHEMBL3841830 | 0.70 | GRIN1 (0.36) | PARP1KDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |