Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | NAAA | Q02083 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858087 | 0.84 | ASAH1 (0.49) | NAAAPOLBALDH1A1ASAH1ACER2 | |
| SCHEMBL16684953 | 0.84 | HDAC1 (0.48) | HDAC7HDAC1HDAC8HDAC3HDAC6 | |
| SCHEMBL9007149 | 0.84 | NAAA (0.51) | HDAC7HDAC1HDAC8HDAC3HDAC6 | |
| Methane SCHEMBL9007169 | 0.83 | NAAA (0.50) | HDAC7HDAC1HDAC8HDAC3HDAC6 | |
| SCHEMBL22471826 | 0.83 | NAAA (0.51) | NAAAMMP2MMP9POLBMMP1 | |
| SCHEMBL22471835 | 0.83 | NAAA (0.51) | NAAAMMP2MMP9POLBMMP1 | |
| SCHEMBL22471814 | 0.83 | NAAA (0.51) | NAAAMMP2MMP9POLBMMP1 | |
| SCHEMBL22471868 | 0.83 | NAAA (0.51) | NAAAMMP2MMP9POLBMMP1 | |
| SCHEMBL4444443 | 0.83 | TBXAS1 (0.51) | NAAAPOLBALDH1A1ASAH1ACER2 | |
| SCHEMBL1911433 | 0.83 | TBXAS1 (0.51) | NAAAPOLBALDH1A1ASAH1ACER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-26 | — | — | US | disclosed |
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ADORA2A, PDE4A, PDE4D | HDAC7 1262/4885HDAC1 2205/4885HDAC8 1366/4885 |
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | BCL6, BCL6B, BCL3 | HDAC7 1034/4885HDAC1 1074/4885HDAC8 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.