Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 4/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989470 | 0.86 | GRM5 (0.40) | KMOCYP2C9ACSS2KCNN4 | |
| SCHEMBL3846649 | 0.86 | HSD11B1 (0.41) | HSD11B1KCNN4KCNA3 | |
| SCHEMBL3847454 | 0.76 | MAOB (0.40) | KMOACSS2KCNN4 | |
| SCHEMBL3846312 | 0.75 | HSD11B1 (0.37) | HSD11B1KMOACP1GRM2EGLN2 | |
| SCHEMBL3858211 | 0.73 | HSD11B1 (0.37) | HSD11B1KMOACP1GRM2EGLN2 | |
| SCHEMBL5800759 | 0.71 | KMT2A (0.52) | KCNN4KCNA3 | |
| SCHEMBL27623829 | 0.70 | MAOB (0.40) | KMO | |
| SCHEMBL19989223 | 0.70 | KDM4E (0.41) | CYP2C9KCNN4KCNA3 | |
| SCHEMBL27930520 | 0.69 | CYP11B1 (0.40) | CYP2C9KCNN4KCNA3 | |
| SCHEMBL28044048 | 0.69 | METAP2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |