Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1458915 | 0.88 | PKM (0.34) | PKMADAM17HTR2CDRD4CHRM2 | |
| SCHEMBL29264392 | 0.81 | PARP1 (0.41) | PKMADAM17MAPK1 | |
| SCHEMBL2042725 | 0.77 | PKM (0.50) | PKMADAM17MAPK1 | |
| SCHEMBL2038319 | 0.76 | PKM (0.49) | PKMADAM17MAPK1 | |
| SCHEMBL2040523 | 0.76 | PKM (0.44) | PKMADAM17DRD4HSD17B10MAPK1 | |
| SCHEMBL4573023 | 0.74 | CHRM2 (0.37) | ADAM17HTR2CCHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL27752387 | 0.74 | SLC6A2 (0.45) | HTR2CHTR2AHTR2B | |
| Bromide SCHEMBL4573068 | 0.73 | CHRM2 (0.36) | PKMADAM17HTR2CCHRM2CHRM1 | |
| SCHEMBL7570449 | 0.73 | DRD4 (0.35) | DRD4 | |
| SCHEMBL30559883 | 0.72 | USP19 (0.39) | HTR2CHSD17B10HTR2AHTR2BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099754-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-16 | — | — | EP | claimed |
| WO-2008073929-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |