Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849684 | 0.80 | RAB9A (0.48) | FLT3MAP3K14EIF2AK4PIK3CAMTOR | |
| SCHEMBL3849418 | 0.79 | NR1H4 (0.52) | S1PR1FLT3MAP3K14PIK3CAMTOR | |
| SCHEMBL3845297 | 0.76 | NPC1 (0.47) | S1PR1FLT3MAP3K14PIK3CAMTOR | |
| SCHEMBL3851554 | 0.76 | TGFBR1 (0.36) | S1PR1FLT3PIK3CAMTORPIK3CB | |
| SCHEMBL3768686 | 0.74 | MAP3K14 (0.48) | FLT3MAP3K14EIF2AK4PIK3CAMTOR | |
| SCHEMBL19586824 | 0.73 | MAP3K14 (0.45) | FLT3MAP3K14EIF2AK4PIK3CAMTOR | |
| SCHEMBL3848981 | 0.73 | PIK3CA (0.33) | S1PR1FLT3PIK3CAMTORPIK3CB | |
| SCHEMBL3848399 | 0.71 | MAP3K14 (0.43) | FLT3MAP3K14EIF2AK4PIK3CAMTOR | |
| SCHEMBL3851193 | 0.71 | MAP3K14 (0.48) | FLT3MAP3K14EIF2AK4PIK3CAMTOR | |
| SCHEMBL3846525 | 0.71 | MAP3K14 (0.48) | FLT3MAP3K14EIF2AK4PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |