Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659631 | 0.79 | KDM4E (0.61) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL7073150 | 0.78 | KDM4E (0.63) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL29956595 | 0.78 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL1039269 | 0.78 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL3843996 | 0.78 | DAO (0.55) | KDM4EHSD17B10ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7075514 | 0.76 | HSD17B10 (0.68) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL21637918 | 0.76 | ALDH1A1 (0.66) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL433980 | 0.75 | BRD4 (0.56) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL3839965 | 0.75 | CBFB (0.52) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL3846952 | 0.75 | TAAR1 (0.36) | KDM4EHSD17B10ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785721-A1 | 3,7-DISUBSTITUTED OCTAHYDRO-2H-PYRIDO[4,3-E][1,3]OXAZIN-2-ONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013080156-A1 | 3,7-DISUBSTITUTED OCTAHYDRO-2H-PYRIDO[4,3-E][1,3]OXAZIN-2-ONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-06-06 | — | — | WO | disclosed |
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |