SCHEMBL384656

SCHEMBL384656

O=C(O)c1cc(C(=O)O)n(-c2ncccc2Cl)n1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
RPA1 P27694 4/20 0.43
MARS1 P56192 3/20 0.43
PPP1CA P62136 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
APOBEC3A P31941 1/20 0.41
APOBEC3G Q9HC16 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
NTRK1 P04629 2/20 0.40
MALT1 Q9UDY8 1/20 0.40
KDM4E B2RXH2 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27917418 0.90 KMT2A (0.38) KMT2AMEN1RPA1MARS1PPP1CA
SCHEMBL958268 0.88 MALT1 (0.40) SMN1; SMN2MALT1LMNA
SCHEMBL29558300 0.88 MALT1 (0.40) SMN1; SMN2MALT1LMNA
SCHEMBL30912707 0.87 KMT2A (0.42) KMT2AMEN1RPA1MARS1PPP1CA
SCHEMBL27727923 0.87 MALT1 (0.39) SMN1; SMN2MALT1LMNA
SCHEMBL45318 0.87 KMT2A (0.41) KMT2AMEN1RPA1MARS1PPP1CA
SCHEMBL535475 0.86 DHODH (0.41) SMN1; SMN2MALT1LMNA
SCHEMBL950148 0.86 ALDH1A1 (0.43) KMT2AMEN1L3MBTL1SMN1; SMN2NTRK1
SCHEMBL29361008 0.86 DHODH (0.41) SMN1; SMN2MALT1LMNA
SCHEMBL19086951 0.86 MALT1 (0.38) SMN1; SMN2MALT1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8946236-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2015-02-03 US disclosed
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2013-12-05 US disclosed
US-8536092-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2012-04-19 US disclosed
US-8101550-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2012-01-24 US disclosed
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-02-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KMT2A 417/4885MEN1 1727/4885RPA1 3333/4885
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KMT2A 417/4885MEN1 1727/4885RPA1 3333/4885
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR KMT2A 417/4885MEN1 1727/4885RPA1 3333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.