Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | LGMN | Q99538 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186988 | 0.84 | MAPT (0.57) | ALDH1A1MAPTKDM4EMAPK1HPGD | |
| SCHEMBL3845241 | 0.83 | NCF1 (0.61) | ALDH1A1KDM4EMAPK1TSHRHSD17B10 | |
| SCHEMBL22441527 | 0.83 | MAPK1 (0.69) | ALDH1A1KDM4EMAPK1HPGDHSD17B10 | |
| SCHEMBL14145384 | 0.82 | NCF1 (0.60) | ALDH1A1MAPTKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL3848428 | 0.81 | NCF1 (0.56) | ALDH1A1NCF1 | |
| SCHEMBL18914675 | 0.80 | LGMN (0.54) | ALDH1A1MAPTKDM4EMAPK1HPGD | |
| SCHEMBL15578242 | 0.80 | MAPT (0.54) | ALDH1A1MAPTKDM4EMAPK1HPGD | |
| SCHEMBL29387438 | 0.80 | MAPT (0.54) | ALDH1A1MAPTKDM4EMAPK1HPGD | |
| SCHEMBL25031345 | 0.79 | MEN1 (0.61) | ALDH1A1MAPTKDM4EMAPK1HPGD | |
| SCHEMBL30479049 | 0.79 | MEN1 (0.61) | ALDH1A1MAPTKDM4EMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |