Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | GOT1 | P17174 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848420 | 0.90 | DRD2 (0.42) | PDGFRBKDM4EMAPTMAPK1 | |
| SCHEMBL3846078 | 0.88 | PDGFRB (0.39) | PDGFRBKDM4EMAPTMAPK1 | |
| SCHEMBL3849677 | 0.87 | MEN1 (0.41) | PDGFRBKDM4EMAPTMAPK1 | |
| SCHEMBL3846241 | 0.86 | DRD2 (0.43) | PDGFRBKDM4EMAPTMAPK1 | |
| SCHEMBL3846433 | 0.86 | AKR1C3 (0.42) | PDGFRBKDM4EMAPTMAPK1GAA | |
| SCHEMBL3848852 | 0.84 | ALDH1A1 (0.43) | KDM4EMAPK1 | |
| SCHEMBL3846765 | 0.83 | ALDH1A1 (0.44) | PDGFRBKDM4EMAPTFAAHMAPK1 | |
| SCHEMBL3848411 | 0.83 | PIK3CA (0.37) | PDGFRB | |
| SCHEMBL3846609 | 0.83 | MTOR (0.37) | PDGFRBKDM4EMAPTMAPK1 | |
| SCHEMBL3846957 | 0.82 | NCF1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |