SCHEMBL384675

SCHEMBL384675

COCCOc1ccc(C(=O)OC)c(OCCOC)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.53
TDP1 Q9NUW8 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
RAB9A P51151 1/20 0.47
INPPL1 O15357 1/20 0.45
HSP90AA1 P07900 2/20 0.44
HTT P42858 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
HDAC1 Q13547 1/20 0.43
KDM4E B2RXH2 1/20 0.43
MAOA P21397 2/20 0.42
MAOB P27338 2/20 0.42
CHEK1 O14757 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
TP53 P04637 1/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
HPGD P15428 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5234224 0.94 MAPT (0.50) MAPTTDP1RAB9AHSP90AA1HTT
SCHEMBL385093 0.89 MAPT (0.51) MAPTTDP1L3MBTL1RAB9AINPPL1
SCHEMBL16482859 0.87 MAOA (0.54) MAPTTDP1L3MBTL1HSP90AA1HTT
SCHEMBL28519834 0.87 TDP1 (0.51) MAPTTDP1L3MBTL1KDM4EMAOA
SCHEMBL3900807 0.86 CA12 (0.60) MAPTL3MBTL1RAB9AMAOBTP53
SCHEMBL20982560 0.86 MAPT (0.56) MAPTTDP1L3MBTL1RAB9AHTT
SCHEMBL27009298 0.85 ALDH1A1 (0.54) MAPTL3MBTL1INPPL1KDM4EALDH1A1
SCHEMBL4447935 0.85 LMNA (0.51) MAPTL3MBTL1INPPL1KDM4EMAOB
SCHEMBL25344842 0.84 FFAR4 (0.57) MAPTTDP1L3MBTL1RAB9AHSP90AA1
SCHEMBL257677 0.84 TDP1 (0.46) MAPTTDP1L3MBTL1RAB9AHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240019746-A1 ULTRA-HIGH-POLARITY CHIRAL LIQUID CRYSTAL MATERIAL, LIQUID CRYSTAL LASER AND PREPARATION METHOD THEREFOR SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) 2024-01-18 US disclosed
US-20240019746-A1 ULTRA-HIGH-POLARITY CHIRAL LIQUID CRYSTAL MATERIAL, LIQUID CRYSTAL LASER AND PREPARATION METHOD THEREFOR SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) 2024-01-18 US disclosed
US-20240019746-A1 ULTRA-HIGH-POLARITY CHIRAL LIQUID CRYSTAL MATERIAL, LIQUID CRYSTAL LASER AND PREPARATION METHOD THEREFOR SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) 2024-01-18 US disclosed
WO-2022089501-A1 ULTRA-HIGH-POLARITY CHIRAL LIQUID CRYSTAL MATERIAL, LIQUID CRYSTAL LASER AND PREPARATION METHOD THEREFOR 华南理工大学 2022-05-05 WO disclosed
US-8101625-B2 Pyrimidinones as Casein Kinase II (CK2) modulators EXELIXIS, INC. (US) 2012-01-24 US disclosed
EP-1948617-B1 PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS EXELIXIS INC (US) 2011-07-27 EP disclosed
US-20090215803-A1 Pyrimidinones as Casein Kinase II (CK2) Modulators EXELIXIS, INC. 2009-08-27 US disclosed
EP-1948617-A2 PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS Exelixis, Inc. (US) 2008-07-30 EP disclosed
WO-2007048065-A2 PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS EXELIXIS, INC. (US) 2007-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215803-A1 Pyrimidinones as Casein Kinase II (CK2) Modulators CSNK2A1, CSNK1A1, CSNK2A2 MAPT 1859/4885TDP1 2331/4885L3MBTL1 4360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.