Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22412884 | 0.73 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL28377697 | 0.73 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL6215102 | 0.69 | KDM4E (0.68) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL11407980 | 0.67 | MEN1 (0.65) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL28210239 | 0.67 | HCAR2 (0.45) | SMN1; SMN2NPC1RAB9ATRPM8LMNA | |
| SCHEMBL27629277 | 0.66 | NPC1 (0.54) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL1690729 | 0.66 | RAB9A (0.50) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL22412717 | 0.66 | TRPM8 (0.63) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL15414899 | 0.66 | TRPM8 (0.39) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 | |
| SCHEMBL22496063 | 0.66 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |