Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846149 | 0.93 | PDE4A (0.43) | TNFADORA2BPDE4AADORA2APDE4B | |
| SCHEMBL3284182 | 0.87 | TNF (0.44) | TNFADORA2BLMNATSHRNR2F2 | |
| SCHEMBL3285813 | 0.85 | ADORA2B (0.43) | TNFADORA2BLMNATSHRNR2F2 | |
| SCHEMBL3290916 | 0.79 | PDE4A (0.41) | TNFADORA2BPDE4AADORA2APDE4B | |
| SCHEMBL3844340 | 0.78 | CTSK (0.39) | TNFADORA2BLMNATSHRNR2F2 | |
| SCHEMBL3288166 | 0.77 | TNF (0.38) | TNFADORA2BLMNATSHRNR2F2 | |
| SCHEMBL3284453 | 0.77 | TNF (0.38) | TNFADORA2BLMNATSHRNR2F2 | |
| SCHEMBL3288315 | 0.76 | ADORA3 (0.49) | ADORA2BTSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL3285814 | 0.76 | CTSK (0.60) | TNFADORA2BSMN1; SMN2NPSR1PDE4A | |
| SCHEMBL3284102 | 0.75 | PTGS1 (0.41) | TNFADORA2BLMNATSHRNR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328886-B1 | DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS | PF MEDICAMENT (FR) | 2016-12-28 | — | — | EP | disclosed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |