Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845311 | 0.87 | ATM (0.38) | PIK3CAGRM4PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3851426 | 0.86 | ATM (0.36) | PIK3CAGRM4PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3847626 | 0.82 | CSNK1D (0.39) | PIK3CAGRM4CSNK1DCSNK1E | |
| SCHEMBL3852071 | 0.82 | MAPK14 (0.36) | PIK3CAGRM4CSNK1DCSNK1E | |
| SCHEMBL3855586 | 0.79 | LMNA (0.39) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3849386 | 0.78 | MAPK14 (0.37) | PIK3CAGRM4CSNK1DCSNK1E | |
| SCHEMBL3847140 | 0.78 | CSNK1D (0.35) | PIK3CACSNK1DCSNK1E | |
| SCHEMBL3852041 | 0.78 | TDO2 (0.49) | TDO2PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3847727 | 0.77 | PIK3CD (0.41) | PIK3CAGRM4CSNK1DCSNK1EMTOR | |
| SCHEMBL3850507 | 0.77 | MAP4K4 (0.37) | PIK3CACSNK1DCSNK1EMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |