Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846869 | 0.88 | TGFBR1 (0.35) | MAPK14TGFBR1PIK3CACSNK1DCSNK1E | |
| SCHEMBL3847626 | 0.85 | CSNK1D (0.39) | MAPK14PIK3CACSNK1DCSNK1EGRM4 | |
| SCHEMBL3846586 | 0.84 | PIK3CA (0.39) | MAPK14TGFBR1PIK3CAGRM4ACVR1 | |
| SCHEMBL3857330 | 0.83 | THRB (0.31) | MAPK14TGFBR1CSNK1DCSNK1EKCNH2 | |
| SCHEMBL3847285 | 0.82 | TDO2 (0.38) | PIK3CACSNK1DCSNK1EGRM4 | |
| SCHEMBL3847727 | 0.82 | PIK3CD (0.41) | PIK3CACSNK1DCSNK1EGRM4MAP4K4 | |
| SCHEMBL3849386 | 0.81 | MAPK14 (0.37) | MAPK14PIK3CACSNK1DCSNK1EGRM4 | |
| SCHEMBL3849997 | 0.79 | CA12 (0.39) | MAPK14PIK3CACSNK1DCSNK1EKCNH2 | |
| SCHEMBL3850507 | 0.79 | MAP4K4 (0.37) | PIK3CACSNK1DCSNK1EMAP4K4AKT1 | |
| SCHEMBL3847543 | 0.79 | PIK3CA (0.34) | MAPK14PIK3CACSNK1DCSNK1EGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |