Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KDM1A | O60341 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564521 | 0.86 | ALDH1A1 (0.60) | KMT2AMEN1KDM1AMAOANPSR1 | |
| SCHEMBL5911665 | 0.85 | KDM1A (0.68) | KMT2AMEN1KDM1AMAOAALDH1A1 | |
| SCHEMBL5911698 | 0.84 | KMT2A (0.62) | KMT2AMEN1KDM1AMAOANPSR1 | |
| SCHEMBL30209696 | 0.82 | MEN1 (0.67) | KMT2AMEN1KDM1AMAOANPSR1 | |
| SCHEMBL27228854 | 0.78 | MEN1 (0.60) | KMT2AMEN1KDM1AMAOANPSR1 | |
| SCHEMBL6278342 | 0.78 | NPSR1 (0.59) | KMT2AMEN1KDM1AMAOANPSR1 | |
| SCHEMBL6595568 | 0.75 | KMT2A (0.49) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3621458 | 0.75 | ALDH1A1 (0.58) | KMT2AMEN1KDM1AALDH1A1NPC1 | |
| SCHEMBL27630068 | 0.75 | KMT2A (0.80) | KMT2AMEN1ALDH1A1GAALMNA | |
| SCHEMBL27183041 | 0.74 | RAB9A (0.47) | KMT2AMEN1ALDH1A1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |