Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333195 | 0.90 | ADRA1D (0.50) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL1333252 | 0.88 | ABCB1 (0.56) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL1333914 | 0.85 | HTR1A (0.59) | HTR1ASLC6A4ABCB1KCNH2 | |
| SCHEMBL1334517 | 0.82 | ABCB1 (0.60) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL2567216 | 0.78 | HTR1A (0.53) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL1332009 | 0.78 | HTR1A (0.52) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL2574419 | 0.78 | HTR1A (0.52) | HTR1ASLC6A4ABCB1 | |
| SCHEMBL5276521 | 0.78 | ACHE (0.61) | HTR1ASLC6A4 | |
| SCHEMBL1334361 | 0.77 | HTR1A (0.55) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL1332119 | 0.77 | HTR1A (0.51) | HTR1ASLC6A4ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1978959-A4 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-09-02 | — | — | EP | disclosed |
| EP-1978959-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008096189-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2008-08-14 | — | — | WO | disclosed |