Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849617 | 0.87 | PIK3CD (0.36) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3847727 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3848662 | 0.86 | PTGS2 (0.35) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3851462 | 0.82 | PIK3CD (0.33) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3855586 | 0.81 | LMNA (0.39) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3846869 | 0.81 | TGFBR1 (0.35) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3848456 | 0.80 | PTGS2 (0.46) | MAPK14PTGS2 | |
| SCHEMBL3850268 | 0.80 | PTGS2 (0.46) | MAPK14PTGS2 | |
| SCHEMBL3850507 | 0.80 | MAP4K4 (0.37) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3850673 | 0.79 | AURKB (0.36) | PIK3CDPIK3CAPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |