Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK1 | Q8N5S9 | 4/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847105 | 0.93 | CAMKK2 (0.47) | CAMKK1CAMKK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3848964 | 0.88 | CAMKK1 (0.39) | CAMKK1CAMKK2 | |
| SCHEMBL3847597 | 0.86 | MAPT (0.40) | CAMKK1CAMKK2PIK3CAMTORAURKB | |
| SCHEMBL3846835 | 0.85 | MAPT (0.41) | KCNH2 | |
| SCHEMBL3846919 | 0.83 | NPC1 (0.43) | CAMKK1CAMKK2PIK3CAMTOR | |
| SCHEMBL3847931 | 0.82 | AURKB (0.43) | CAMKK1CAMKK2AURKBEGFRERBB2 | |
| SCHEMBL3845338 | 0.80 | LMNA (0.40) | CAMKK1CAMKK2 | |
| SCHEMBL3846747 | 0.80 | RPS6KB2 (0.39) | CAMKK1CAMKK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3845224 | 0.76 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL3847825 | 0.75 | SMN1; SMN2 (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |