Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.40 |
| ▸ | DRD3 | P35462 | 7/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846469 | 0.87 | HTR7 (0.45) | DRD2DRD3HTR7SIGMAR1SLC6A2 | |
| SCHEMBL3844666 | 0.86 | DRD2 (0.40) | DRD2DRD3VCPHTR7SIGMAR1 | |
| SCHEMBL3844664 | 0.82 | AGXT (0.42) | DRD2DRD3HTR7SLC6A2SLC6A4 | |
| SCHEMBL3845294 | 0.82 | DRD2 (0.43) | DRD2DRD3VCPHTR7 | |
| SCHEMBL3848596 | 0.82 | DRD2 (0.42) | DRD2DRD3VCPHTR7SLC6A2 | |
| SCHEMBL3844657 | 0.80 | DRD2 (0.45) | DRD2DRD3VCPHTR7 | |
| SCHEMBL3844088 | 0.80 | ADRA2C (0.45) | DRD2DRD3HTR7 | |
| SCHEMBL3845098 | 0.79 | DRD2 (0.48) | DRD2DRD3HTR7SIGMAR1 | |
| SCHEMBL3849898 | 0.79 | DRD2 (0.58) | DRD2DRD3HTR7SIGMAR1 | |
| SCHEMBL3848584 | 0.79 | DRD2 (0.41) | DRD2DRD3VCPHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038268-A2 | CARBONYLATED (AZA)CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007148208-A2 | CARBONYLATED (AZA) CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-27 | — | — | WO | disclosed |