Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | YAP1 | P46937 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3845139 | 0.93 | ALDH1A1 (0.43) | ALDH1A1LMNAKDM4EGAAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3850494 | 0.92 | ALDH1A1 (0.45) | ALDH1A1LMNAKDM4EGAAL3MBTL1 | |
| Bromide SCHEMBL15258667 | 0.90 | ALDH1A1 (0.43) | ALDH1A1LMNAKDM4EGAAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4114930 | 0.81 | NPC1 (0.43) | ALDH1A1LMNAKDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3847306 | 0.81 | HPGD (0.37) | ALDH1A1LMNAKDM4EGAAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3847607 | 0.81 | L3MBTL3 (0.44) | ALDH1A1KDM4EGAAL3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL3844455 | 0.80 | KDM4E (0.44) | ALDH1A1KDM4EGAAL3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL3845763 | 0.77 | MAPT (0.57) | ALDH1A1LMNAKDM4EGAAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3849505 | 0.77 | SMN1; SMN2 (0.53) | ALDH1A1LMNAKDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3843819 | 0.76 | DPP4 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2085086-A2 | Method for treating congestive heart failure or diabetic nephropathy | Synvista Therapeutics, Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1305024-A4 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS IC | ALTEON INC (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1305024-A1 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS IC | Alteon, Inc. (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002007725-A1 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS IC | ALTEON, INC. (US) | 2002-01-31 | — | — | WO | disclosed |