Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | BRS3 | P32247 | 2/20 | 0.37 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849352 | 0.87 | L3MBTL1 (0.42) | TGFBR1SLC6A3SLC6A4MEN1ALDH1A1 | |
| SCHEMBL3849273 | 0.83 | TGFBR1 (0.40) | TGFBR1TGFBR2 | |
| SCHEMBL3852197 | 0.82 | TGFBR1 (0.40) | TGFBR1SLC6A3SLC6A4BRS3MAPT | |
| SCHEMBL3849268 | 0.82 | TGFBR1 (0.38) | TGFBR1TGFBR2 | |
| SCHEMBL3845976 | 0.80 | TGFBR1 (0.40) | TGFBR1TGFBR2 | |
| SCHEMBL3847131 | 0.80 | KCNH2 (0.41) | TGFBR1 | |
| SCHEMBL3853919 | 0.80 | TGFBR1 (0.33) | TGFBR1 | |
| SCHEMBL3851642 | 0.80 | TGFBR1 (0.45) | TGFBR1EPHB3TGFBR2 | |
| SCHEMBL3850019 | 0.80 | L3MBTL1 (0.41) | TGFBR1BRS3MEN1ALDH1A1KMT2A | |
| SCHEMBL3845039 | 0.79 | TGFBR1 (0.46) | TGFBR1ALDH1A1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |