Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853393 | 0.93 | MAPK14 (0.32) | ALDH1A1MAPTPIK3R2MAP3K14CDK9 | |
| SCHEMBL3845874 | 0.92 | CDK9 (0.34) | ALDH1A1MAPTATMFGFR1CDK9 | |
| SCHEMBL3854592 | 0.86 | FGFR1 (0.35) | ALDH1A1MAPTFGFR1 | |
| SCHEMBL3850336 | 0.84 | ALDH1A1 (0.34) | ALDH1A1MAPTPRPS1 | |
| SCHEMBL3849277 | 0.79 | JAK2 (0.35) | PIK3R2FGFR1CDK9 | |
| SCHEMBL3847147 | 0.79 | FGFR1 (0.39) | ALDH1A1MAPTFGFR1 | |
| Hydrochloric Acid SCHEMBL3847895 | 0.78 | MAPT (0.36) | ALDH1A1MAPTPIK3R2ATMPRPS1 | |
| SCHEMBL3846713 | 0.78 | POLB (0.41) | PIK3R2CDK9 | |
| SCHEMBL3853395 | 0.78 | — | — | |
| SCHEMBL3850666 | 0.78 | JAK2 (0.34) | PIK3R2FGFR1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |