Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | LHCGR | P22888 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10089396 | 0.77 | ALDH1A1 (0.76) | RAB9AALDH1A1EPHX1FAAHLHCGR | |
| SCHEMBL10089405 | 0.77 | ALDH1A1 (0.76) | RAB9AALDH1A1EPHX1FAAHLHCGR | |
| SCHEMBL1532563 | 0.76 | ALDH1A1 (1.00) | RAB9AALDH1A1EPHX1FAAHLHCGR | |
| SCHEMBL21618461 | 0.76 | ALDH1A1 (1.00) | RAB9AALDH1A1EPHX1FAAHLHCGR | |
| SCHEMBL8393776 | 0.76 | ALDH1A1 (1.00) | RAB9AALDH1A1EPHX1FAAHLHCGR | |
| SCHEMBL2905964 | 0.76 | POLB (0.49) | RAB9ATHRBEPHX2SMN1; SMN2POLB | |
| Bicarbonate SCHEMBL15226094 | 0.74 | ALDH1A1 (0.97) | RAB9AALDH1A1EPHX1FAAHLHCGR | |
| SCHEMBL5115600 | 0.73 | ALDH1A1 (0.97) | RAB9AALDH1A1EPHX1FAAHLHCGR | |
| SCHEMBL4234112 | 0.73 | MEN1 (0.64) | RAB9AALDH1A1EPHX1FAAHEPHX2 | |
| SCHEMBL28891768 | 0.73 | CYP1A2 (0.73) | RAB9AALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809822-B2 | Triptolide derivatives and preparation method and use thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-11-07 | — | — | US | claimed |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-12-15 | — | — | US | claimed |
| US-9809822-B2 | Triptolide derivatives and preparation method and use thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-11-07 | — | — | US | disclosed |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-12-15 | — | — | US | disclosed |
| EP-1730228-B1 | NANO-COMPOSITE AND METHOD THEREOF | BRIDGESTONE CORP (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-7579398-B2 | Nano-composite and compositions therefrom | BRIDGESTONE CORPORATION (JP) | 2009-08-25 | — | — | US | disclosed |
| US-7572855-B2 | Nano-composite and compositions manufactured thereof | BRIDGESTONE CORPORATION (JP) | 2009-08-11 | — | — | US | disclosed |
| US-20090182087-A1 | NANO-COMPOSITE AND COMPOSITIONS THEREFROM | BRIDGESTONE CORPORATION (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1730228-A1 | NANO-COMPOSITE AND METHOD THEREOF | Bridgestone Corporation (JP) | 2006-12-13 | — | — | EP | disclosed |
| US-20060173115-A1 | Nano-composite and compositions manufactured thereof | BRIDGESTONE CORPORATION (JP) | 2006-08-03 | — | — | US | disclosed |
| WO-2005095506-A1 | NANO-COMPOSITE AND METHOD THEREOF | BRIDGESTONE CORPORATION (JP) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | TPD52L2, TRDMT1, MCTS1 | RAB9A 2995/4885ALDH1A1 2399/4885THRB 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.